[Diffusion and perfusion magnetic resonance imaging in evaluation of primary glial brain tumors].

INTRODUCTION: Diffusion (DWI) and perfusion (PWI) imaging can give important data about physiological characteristics of tissue, which complete morphologic findings from conventional MRI. The aim of this study is to estimate the value of these MRI technics in evaluation of primary glial brain tumors. MATERIALS AND METHODS: The significance of DWI and PWI in differentiation of histologically proven low- and high-grade gliomas was estimated in 48 patient with diagnosed brain gliomas. ADC and rCBV values were compared by aplication of Mann-Whitney test, and logistic regression analysis was used to determine which of these two parameters contributed the most in increasing the diagnostic accuracy, ia. its sensitivity, specificity and predictive velues. ROC curves were constructed to determine threshold values for differentiation of low- from high-grade lesions. RESULTS: Statistical significance were showed between mean values of rCBV for low-grade (0.82) and high-grade (5.32) gliomas, which was not found for values of ADC parameters. Threshold rCBV value of 1.23 was determinated for discrimination between low- and high-grade gliomas with a sensitivity of 83.2% and a specificity of 77.5%. CONCLUSION: Conventional MRI combined with PWI increases the accuracy in determination of glioma grade.

[Comparative evaluation of conventinal and dynamic magnetic resonance imaging, of the pituitary microadenomas].

OBJECTIVE: This study tried to determine if there is a difference between standard and dynamic MR examination in detection of pituitary microadenoma. SUBJECTS AND METHODS: We have included twenty seven patients with suspicious pituitary tumor. All patients have been hospitalized for endocrinology examination between June 2007 and May 2008 in Institute for Endocrinology, diabetes and metabolic diseases of Clinical Center of Serbia. MR examinations have been preformed in MR Center of Clinical Center of Serbia. RESULTS: Twenty seven patients were included in our study. Only in four of them pituitary microadenoma was detected using dynamic MR examination. One was somatotrophin secreting adenoma, and three were corticotrophin realizing adenomas. There were no statistically significant differences between conventional and dynamic MR examination. CONCLUSION: Dynamic MR Examination as method can hardly match standard MR examination which remains standard in detection of pituitary microadenomas.